TABLE 1.

Function and related target of lncRNAs in SARS-CoV-2 infection.

Related target	lncRNA	Initial function	Immune response	Reference
IFN	lncRNA-CMPK2	Blocking the transcription of ISGs	Limit innate immune	Enguita et al. (2022)
	EGOT	Downregulate the expression of several ISGs	Limit innate immune	Mukherjee et al. (2021)
	LUCAT1	Reduce the expression of STAT-targets CXCR4 and NAMPT	Limit innate immune	Aznaourova et al. (2022)
	CHROMR	Promote the transcription of ISGs	Promote innate immune	van Solingen et al. (2022)
	lnc02384	Increase the production of IFN-γ	Promote innate immune	Moazzam‐Jazi et al. (2021)
	NETA1	Promote the expression of DDX60 and RIG-I	Promote innate immune	Ma et al. (2017)
TNF-α/IL-10	GAS5	Induced NLRP3、IL-10、TNF-α	Inflammation	Morenikeji et al. (2021)
NF-κB	LUCAT1	Induced expression of proinflammatory markers CXCL2 and CXCL8	Inflammation	Aznaourova et al. (2022)
	PIRAT	Reduce alarmin production	Inflammation	Aznaourova et al. (2022)
	KCNQ1OT1	Interact with upregulated TLR2	Inflammation	Turjya et al. (2020)
	NORAD	Induced IL-6、IL-10、CSF3、CXCL10、TNF-α	Inflammation	Morenikeji et al. (2021)
	RAD51-AS1	Induced IL-6、TNF-α、CCL2	Inflammation	Morenikeji et al. (2021)
	MALAT1	Induced TNF-α、IL-6、IL-1 and CCL2	Inflammation	Moazzam‐Jazi et al. (2021)
	NEAT1	Induced TNF-α, IL-6, and IL-1, NLRP3, as well as CCl2, Ccl3, and CXCL10	Inflammation	Moazzam‐Jazi et al. (2021)
Th17 cell differentiation	CCR7-AS-1, LEF1-AS-1	T cell activation and differentiation	Adaptive immune	Zheng et al. (2020)
	LINC-CCR7-2
	LINC-TCF7-1
	TCF7-AS -1
MAPK	LINC-JUND-1, LINC-HSP90AA1-1, HIF1A-AS-	T cell activation and differentiation	Adaptive immune	Zheng et al. (2020)