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. 1989 Jan;73(1):1–5. doi: 10.1136/bjo.73.1.1

Long-term follow-up of retinal blood flow in diabetes using the blue light entoptic phenomenon.

T Rimmer 1, T J Fallon 1, E M Kohner 1
PMCID: PMC1041631  PMID: 2920149

Abstract

The blue light entopic phenomenon was used to measure retinal blood flow in 87 diabetics and 10 normal controls in a longitudinal study. The time interval between the initial and final studies was 21-39 months (mean 31.4). The retinal blood flow velocity did not change in the 10 subjects in the control group nor in those nine patients with no retinopathy, all but one of whom remained free of retinal lesions. In the 24 with background retinopathy the flow velocity fell significantly from 0.71 (SD 0.35) mm/s to 0.48 (0.13) mm/s (p less than 0.01). The velocity also decreased in the preproliferative group of 16 patients from 0.62 (0.39) mm/s to 0.41 (0.14) mm/s (p less than 0.05). The retinopathy status changed in 11 of this group. In those with proliferative retinopathy (now treated) and those treated previously there was no change in flow velocity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Atherton A., Hill D. W., Keen H., Young S., Edwards E. J. The effect of acute hyperglycaemia on the retinal circulation of the normal cat. Diabetologia. 1980 Mar;18(3):233–237. doi: 10.1007/BF00251922. [DOI] [PubMed] [Google Scholar]
  2. Baba Y., Kai M., Kamada T., Setoyama S., Otsuji S. Higher levels of erythrocyte membrane microviscosity in diabetes. Diabetes. 1979 Dec;28(12):1138–1140. doi: 10.2337/diab.28.12.1138. [DOI] [PubMed] [Google Scholar]
  3. Bresnick G. H., De Venecia G., Myers F. L., Harris J. A., Davis M. D. Retinal ischemia in diabetic retinopathy. Arch Ophthalmol. 1975 Dec;93(12):1300–1310. doi: 10.1001/archopht.1975.01010020934002. [DOI] [PubMed] [Google Scholar]
  4. Cunha-Vaz J. G. Diabetic retinopathy. Human and experimental studies. Trans Ophthalmol Soc U K. 1972;92:111–124. [PubMed] [Google Scholar]
  5. Dintenfass L. Blood viscosity factors in severe nondiabetic and diabetic retinopathy. Biorheology. 1977;14(4):151–157. doi: 10.3233/bir-1977-14401. [DOI] [PubMed] [Google Scholar]
  6. Fallon T. J., Chowiencyzk P., Kohner E. M. Measurement of retinal blood flow in diabetes by the blue-light entoptic phenomenon. Br J Ophthalmol. 1986 Jan;70(1):43–46. doi: 10.1136/bjo.70.1.43. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fallon T. J., Sleightholm M. A., Merrick C., Chahal P., Kohner E. M. The effect of acute hyperglycemia on flow velocity in the macular capillaries. Invest Ophthalmol Vis Sci. 1987 Jun;28(6):1027–1030. [PubMed] [Google Scholar]
  8. Feke G. T., Tagawa H., Yoshida A., Goger D. G., Weiter J. J., Buzney S. M., McMeel J. W. Retinal circulatory changes related to retinopathy progression in insulin-dependent diabetes mellitus. Ophthalmology. 1985 Nov;92(11):1517–1522. doi: 10.1016/s0161-6420(85)33827-7. [DOI] [PubMed] [Google Scholar]
  9. Grunwald J. E., Riva C. E., Brucker A. J., Sinclair S. H., Petrig B. L. Altered retinal vascular response to 100% oxygen breathing in diabetes mellitus. Ophthalmology. 1984 Dec;91(12):1447–1452. doi: 10.1016/s0161-6420(84)34124-0. [DOI] [PubMed] [Google Scholar]
  10. Grunwald J. E., Riva C. E., Sinclair S. H., Brucker A. J., Petrig B. L. Laser Doppler velocimetry study of retinal circulation in diabetes mellitus. Arch Ophthalmol. 1986 Jul;104(7):991–996. doi: 10.1001/archopht.1986.01050190049038. [DOI] [PubMed] [Google Scholar]
  11. HORSTMANN P. The oxygen consumption in diabetes mellitus. Acta Med Scand. 1951;139(4):326–330. doi: 10.1111/j.0954-6820.1951.tb17171.x. [DOI] [PubMed] [Google Scholar]
  12. Kohner E. M., Hamilton A. M., Saunders S. J., Sutcliffe B. A., Bulpitt C. J. The retinal blood flow in diabetes. Diabetologia. 1975 Feb;11(1):27–33. doi: 10.1007/BF00422814. [DOI] [PubMed] [Google Scholar]
  13. Little H. L. The role of abnormal hemorrheodynamics in the pathogenesis of diabetic retinopathy. Trans Am Ophthalmol Soc. 1976;74:573–636. [PMC free article] [PubMed] [Google Scholar]
  14. McMillan D. E., Utterback N. G., La Puma J. Reduced erythrocyte deformability in diabetes. Diabetes. 1978 Sep;27(9):895–901. doi: 10.2337/diab.27.9.895. [DOI] [PubMed] [Google Scholar]
  15. McMillan D. E., Utterback N. G., Sparks L. L., Bramwell P. C. Impaired erythrocyte doublet formation in diabetes. Diabetologia. 1981 Dec;21(6):575–578. doi: 10.1007/BF00281552. [DOI] [PubMed] [Google Scholar]
  16. Oakley N., Hill D. W., Joplin G. F., Kohner E. M., Fraser T. R. Diabetic retinopathy. I. The assessment of severity and progress by comparison with a set of standard fundus photographs. Diabetologia. 1967 Aug;3(4):402–405. doi: 10.1007/BF02342633. [DOI] [PubMed] [Google Scholar]
  17. Yoshida A., Feke G. T., Morales-Stoppello J., Collas G. D., Goger D. G., McMeel J. W. Retinal blood flow alterations during progression of diabetic retinopathy. Arch Ophthalmol. 1983 Feb;101(2):225–227. doi: 10.1001/archopht.1983.01040010227008. [DOI] [PubMed] [Google Scholar]

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