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. Author manuscript; available in PMC: 2024 Jan 27.
Published in final edited form as: J Med Chem. 2023 Apr 7;66(8):5657–5668. doi: 10.1021/acs.jmedchem.2c02089

Figure 2. Screening for selective SCoR2 inhibitors.

Figure 2.

(A) Chemical structure of imirestat. (B) Generic structure of imirestat scaffold showing positions (C2, C3, C4, C7) modified in design of new compounds. (C) IC50 value of 57 compounds for inhibition of the DL-glyceraldehyde-metabolizing activity of SCoR2. (D) Chemical structure of JSD26. (E-F) Docked binding model of JSD26 bound to SCoR2. SCoR2 (grey carbons), NADPH (green carbons) and JSD26 (blue carbons). Predicted hydrogen bonds are depicted as dashed lines.