Table 2.
OR (95% CIs) of the prevalence of asthma according to quartiles of complete blood cell (CBC)-derived inflammatory biomarkers among adults in NHANES 1999–2018.
| Quartiles of CBC-derived inflammatory biomarkers levels | P trend | ||||
|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | ||
| NLR | |||||
| Range | <1.43 | 1.43-1.91 | 1.92-2.56 | >2.56 | |
| Crude | 1.00 [Reference] | 1.036(0.939,1.144) | 1.040(0.940,1.151) | 1.113(1.004,1.235) | 0.037 |
| Model 1 | 1.00 [Reference] | 1.068(0.966,1.180) | 1.077(0.971,1.195) | 1.202(1.079,1.339) | <0.001 |
| Model 2 | 1.00 [Reference] | 1.061(0.958,1.177) | 1.042(0.937,1.158) | 1.142(1.024,1.274) | 0.02 |
| PLR | |||||
| Range | <94.8 | 94.8-120.0 | 120.1-152.0 | >152.0 | |
| Crude | 1.00 [Reference] | 1.073(0.978,1.176) | 0.969(0.874,1.076) | 1.068(0.962,1.186) | 0.458 |
| Model 1 | 1.00 [Reference] | 1.047(0.955,1.148) | 0.943(0.848,1.048) | 1.037(0.933,1.152) | 0.808 |
| Model 2 | 1.00 [Reference] | 1.089(0.994,1.193) | 1.000(0.899,1.112) | 1.123(1.012,1.247) | 0.088 |
| MLR | |||||
| Range | <0.20 | 0.20-0.26 | 0.26-0.33 | >0.33 | |
| Crude | 1.00 [Reference] | 0.968(0.884,1.060) | 0.919(0.830,1.017) | 0.967(0.884,1.057) | 0.495 |
| Model 1 | 1.00 [Reference] | 1.018(0.929,1.115) | 1.000(0.903,1.107) | 1.133(1.033,1.244) | 0.007 |
| Model 2 | 1.00 [Reference] | 1.032(0.942,1.130) | 1.019(0.922,1.125) | 1.163(1.060,1.275) | 0.001 |
| SIRI | |||||
| Range | <0.68 | 0.68-1.02 | 1.03-1.50 | >1.50 | |
| Crude | 1.00 [Reference] | 1.064(0.973,1.163) | 1.102(0.993,1.222) | 1.147(1.043,1.262) | 0.005 |
| Model 1 | 1.00 [Reference] | 1.115(1.017,1.223) | 1.191(1.070,1.326) | 1.289(1.165,1.426) | <0.0001 |
| Model 2 | 1.00 [Reference] | 1.080(0.985,1.184) | 1.123(1.008,1.251) | 1.169(1.056,1.293) | 0.004 |
| SII | |||||
| Range | <330.0 | 330.0-466.7 | 466.8-659.5 | >659.5 | |
| Crude | 1.00 [Reference] | 1.065(0.951,1.194) | 1.162(1.041,1.297) | 1.249(1.118,1.394) | <0.0001 |
| Model 1 | 1.00 [Reference] | 1.064(0.950,1.193) | 1.159(1.038,1.295) | 1.234(1.101,1.382) | <0.0001 |
| Model 2 | 1.00 [Reference] | 1.052(0.938,1.181) | 1.119(0.999,1.252) | 1.159(1.031,1.303) | 0.008 |
Data are presented as OR (95% CI) unless indicated otherwise; Model 1 was adjusted as age (continuous), sex (male or female), and race/ethnicity (Mexican American, Other Hispanic, Non-Hispanic White, Non-Hispanic Black or Other); Model 2 was adjusted as model 1 plus education level (below high school, high school, or above high school), family poverty income ratio (≤1.0, 1.1–3.0, or >3.0), drinking status (nondrinker, low-to-moderate drinker, or heavy drinker), smoking status (never smoker, former smoker, or current smoker), BMI (<25.0, 25.0-29.9, or >29.9), physical activity (inactive, insufficiently active, or active), total energy intakes (in quartiles), self-reported diabetes (yes or no), and self-reported hypertension (yes or no).