Table 4.
HRs (95% CIs) of respiratory disease mortality according to quartiles of complete blood cell (CBC)-derived inflammatory biomarkers among adults with asthma in NHANES 1999–2018.
| Quartiles of CBC-derived inflammatory biomarkers levels | P trend | ||||
|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | ||
| NLR | |||||
| Range | <1.43 | 1.43-1.91 | 1.92-2.56 | >2.56 | |
| No. deaths/total | 73/3061 | 84/3066 | 119/3039 | 246/3078 | |
| Crude | 1.00 [Reference] | 0.828 (0.373-1.835) | 1.411 (0.753-2.645) | 4.610 (2.500-8.502) | <0.001 |
| Model 1 | 1.00 [Reference] | 0.774 (0.339-1.765) | 1.365 (0.708-2.631) | 3.121 (1.658-5.875) | <0.001 |
| Model 2 | 1.00 [Reference] | 0.756 (0.342-1.669) | 1.096 (0.551-2.179) | 2.622 (1.376-4.995) | <0.001 |
| PLR | |||||
| Range | <94.8 | 94.8-120.0 | 120.1-152.0 | >152.0 | |
| No. deaths/total | 90/3065 | 112/3091 | 123/3032 | 197/3056 | |
| Crude | 1.00 [Reference] | 0.412 (0.200-0.847) | 0.891 (0.436-1.820) | 1.582 (0.853-2.932) | 0.032 |
| Model 1 | 1.00 [Reference] | 0.385 (0.187-0.791) | 0.742 (0.368-1.497) | 1.133 (0.622-2.065) | 0.203 |
| Model 2 | 1.00 [Reference] | 0.439 (0.223-0.864) | 0.874 (0.460-1.660) | 1.322 (0.781-2.239) | 0.069 |
| MLR | |||||
| Range | <0.20 | 0.20-0.26 | 0.26-0.33 | >0.33 | |
| No. deaths/total | 61/3143 | 71/3008 | 93/2604 | 297/3489 | |
| Crude | 1.00 [Reference] | 0.887 (0.400-1.966) | 1.787 (0.846-3.774) | 4.775 (2.557-8.918) | <0.001 |
| Model 1 | 1.00 [Reference] | 0.785 (0.348-1.770) | 1.264 (0.590-2.708) | 2.390 (1.236-4.622) | <0.001 |
| Model 2 | 1.00 [Reference] | 1.075 (0.465-2.486) | 1.537 (0.746-3.165) | 2.812 (1.507-5.246) | <0.001 |
| SIRI | |||||
| Range | <0.68 | 0.68-1.02 | 1.03-1.50 | >1.50 | |
| No. deaths/total | 62/3058 | 81/3066 | 126/3121 | 253/2999 | |
| Crude | 1.00 [Reference] | 0.852 (0.375-1.936) | 2.367 (1.133-4.945) | 7.015 (3.550-13.863) | <0.001 |
| Model 1 | 1.00 [Reference] | 0.758 (0.331-1.736) | 2.016 (0.919-4.419) | 4.436 (2.187-8.999) | <0.001 |
| Model 2 | 1.00 [Reference] | 0.776 (0.333-1.809) | 1.824 (0.839-3.965) | 3.208 (1.578-6.522) | <0.001 |
| SII | |||||
| Range | <330.0 | 330.0-466.7 | 466.8-659.5 | >659.5 | |
| No. deaths/total | 87/3066 | 107/3056 | 121/3061 | 207/3061 | |
| Crude | 1.00 [Reference] | 0.719 (0.343-1.503) | 1.348 (0.657-2.768) | 3.021 (1.670-5.466) | <0.001 |
| Model 1 | 1.00 [Reference] | 0.793 (0.373-1.682) | 1.452 (0.687-3.068) | 2.630 (1.415-4.889) | <0.001 |
| Model 2 | 1.00 [Reference] | 0.762 (0.344-1.689) | 1.114 (0.536-2.315) | 1.988 (1.043-3.789) | 0.006 |
Data are presented as HR (95% CI) unless indicated otherwise; Model 1 was adjusted as age (continuous), sex (male or female), and race/ethnicity (Mexican American, Other Hispanic, Non-Hispanic White, Non-Hispanic Black or Other); Model 2 was adjusted as model 1 plus education level (below high school, high school, or above high school), family poverty income ratio (≤1.0, 1.1–3.0, or >3.0), drinking status (nondrinker, low-to-moderate drinker, or heavy drinker), smoking status (never smoker, former smoker, or current smoker), BMI (<25.0, 25.0-29.9, or >29.9), physical activity (inactive, insufficiently active, or active), total energy intakes (in quartiles), self-reported diabetes (yes or no), and self-reported hypertension (yes or no).