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. 2023 Aug 11;42:206. doi: 10.1186/s13046-023-02730-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 8 — A Derived ssGSEA scores of immune signatures obtained from STAD gene expression data for the groups of high and low NII score. The range of P values were labeled above each boxplot with asterisks.(ns P > 0.05, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001) B The correlation of immune cells and NII score in the training cohort. The range of P values are represented by color from yellow to green. C The significantly enriched signal pathways from Gene Set Enrichment Analysis (GSEA) performed between the subgroups of high and low NII score in the Multi cohort. D The representative results of multiple immunofluorescence staining of subgroups(PNI with high NII score,PNI with low NII score,non-PNI with high NII score and non-PNI with low NII score).(S100 in red,CD68 in green,CD20 in orange,CD8 in purple,CD4 in white and DAPI in blue.The statistical results were performed in 5 random views of per group under 40X. *P < 0.05; **P < 0.01; ***P < 0.001) E, F The comparing between PNI and non-PNI patients in training cohort and Nanfang cohort 2. G The representative figures of IHC analyse of subgroups(PNI with high NII score, PNI with low NII score and non-PNI patients, CPS scores were obtained from clinical pathological report) accepting anti-PD1 treatment. (S100,CD3,CD8,CD28 and CK were stained with DAB in brown,nucleus were stained with hematoxylin in purple) (H)The statistical result of CD3,CD8 and CD28 were performed in 5 random views of per group under 40X.(*P < 0.05; **P < 0.01; ***P < 0.001)