Table 7.

Effect size of AIP on prediabetes in prespecified and exploratory subgroups

Characteristic	No of patients	HR (95%CI)	P value	P for interaction
Age(years)				< 0.0001
< 60	87,925	1.56 (1.43, 1.70)	< 0.0001
≥ 60	12,144	1.11 (0.96, 1.29)	0.1670
Gender				< 0.0001
Male	51,891	1.23 (1.12, 1.35)	< 0.0001
Female	48,178	1.71 (1.52, 1.92)	< 0.0001
Drinking status				0.0574
Current drinker	638	1.23 (0.53, 2.82)	0.6286
Ever drinker	4533	1.52 (1.11, 2.09)	0.0089
Never drinker	22,374	1.68 (1.45, 1.95)	< 0.0001
Not recorded	72,524	1.34 (1.23, 1.45)	< 0.0001
Smoking status				0.0828
Current-smoker	5308	1.59 (1.20, 2.09)	0.0010
Ex-smoker	1083	1.30 (0.67, 2.50)	0.4402
Never-smoker	21,154	1.69 (1.43, 1.99)	< 0.0001
Not recorded	72,524	1.34 (1.23, 1.45)	< 0.0001
Family history of diabetes				0.3600
No	97,874	1.41 (1.31, 1.51)	< 0.0001
Yes	2195	1.72 (1.12, 2.64)	0.0128
SBP (mmHg)				0.0389
< 140	91,009	1.43 (1.32, 1.55)	< 0.0001
≥ 140	9060	1.18 (1.00, 1.39)	0.0550
DBP (mmHg)				0.5907
< 90	92,459	1.41 (1.31, 1.53)	< 0.0001
≥ 90	7610	1.34 (1.11, 1.61)	0.0025
BMI (kg/m2)				< 0.0001
< 25	73,573	1.76 (1.61, 1.93)	< 0.0001
≥ 25	26,496	1.23 (1.10, 1.37)	0.0002

Note 1: Above model adjusted for gender, age, SBP, DBP, family history of diabetes, drinking status, smoking status, BMI, TC, LDL-C, AST, ALT, Scr, BUN, FPG

Note 2: In each case, the model is not adjusted for the stratification variable