Table 2.

In vivo Nanotechnology-based Scaffold in skin regeneration

Nanomaterial	biomolecule or drug	Model	Major outcomes	Ref
Nanofibrous scaffolds comprising polyvinyl pyrrolidone (PVP), cerium nitrate hexahydrate (Ce(NO3)3·6H2O)	Curcumin(Cur)	Rat full-thickness skin wound model	Scarless wound healing; reduced local oxidative stress	[55]
Dextran based bionanocomposite membranes	Clove oil (CO) and sandalwood oil (SO)	Mouse full-thickness skin wound model	Scarless wound healing; proper collagen formation and organization, and presence of hair follicles	[56]
Sulphonated polyether ether ketone (SPEEK) nanofibrous scaffold	Aloe vera	Rat excision skin wound model	Scarless wound healing; excellent pathogenic inhibition	[57]
Amniotic membrane (AM)/SF membrane	Adipose tissue-derived mesenchymal stem cells	Mouse third degree burn wound model	Scarless wound healing; accelerated wound healing, neo-vascularization and early re-epithelialization	[58]
Ag/Glass–ceramics (GC)-Ch/polyethylene oxide (PEO)/Gel electrospun scaffolds.	Mouse embryonic fibroblasts	Mouse full-thickness skin wound model	Scarless cutaneous wound regeneration; enhanced angiogenesis, and collagen synthesis as well as regeneration of the sebaceous glands and hair follicles	[59]
Silver-catechin nanocomposite tethered collagen scaffolds	Silver-catechin nanocomposite	Rat full-thickness skin wound model	Scarless wound healing; increased angiogenesis	[60]
ZnO–curcumin nanocomposite tethered collagen scaffolds	ZnO–curcumin nanocomposite	Rat burn wound healing model	Scarless wound healing; upregulates angiogenesis and TGF-β3 expression thereby	[61]