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. Author manuscript; available in PMC: 2023 Aug 11.
Published in final edited form as: Antiviral Res. 2022 May 6;203:105330. doi: 10.1016/j.antiviral.2022.105330

Fig. 5.

Fig. 5.

FR-S inhibits DENV-2 NS1-induced vascular leak in the mouse dermis. (A) Each C57BL/6 mouse was intradermally injected in the dorsal dermis with four different treatments (PBS, PBS + FR-S, PBS + NS1, and NS1 + FR-S) and then administered Alexa Fluor 680-conjugated 10 kDa dextran (5 mg/mL) via retro-orbital injection. Two hours later, mice were euthanized, and the dorsal dermis was removed and scanned using a LI-COR Odyssey CLx Imaging System. (B) Images were analyzed using ImageJ to obtain mean fluorescence intensity values, which were expressed as fold-change in comparison to PBS treatment. Treatment groups (N = 6) were compared by one-way ANOVA + Tukey’s test. Asterisk (*) indicates significant difference, with p < 0.05.