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. 2023 Jul 28;14:1215110. doi: 10.3389/fpsyt.2023.1215110

Figure 2.

Figure 2

Brain-wide expression of CUL3 in humans and mice. (A) Plots depicting CUL3 expression in different regions of the human brain during fetal development (period 1–7), early (period 8–9), young adulthood (period 10–11), adolescence (period 12), and adulthood (period 13–15). Regions include neocortex (NCX), hippocampus (HIP), amygdala (AMY), striatum (STR), medial dorsal thalamus (MD), and cerebellar cortex (CBC). Data obtained from the human brain transcriptome dataset (https://hbatlas.org/, search gene CUL3). (B,C) Schematic (B) and bar graph (C) of Cul3 expression in different mouse brain regions using high-throughput gene expression profiling. Data obtained from bioGPS (http://ds.biogps.org/, search gene Cul3). One–Way ANOVA with Holm-Sidak multiple comparisons test compared to the averaged whole-brain expression, * p < 0.05. (D,E) Representative sagittal sections (D) and bar graph (E) of in-situ hybridization of Cul3 mRNA signals in mouse brains. Data obtained from the Allen Institute ISH database (https://mouse.brain-map.org/, search gene Cul3, experiment 75774648).