Faster CMRgl decline in BDNF Met than BDNF Val/Val among АРОЕ4с, as compared to same directional difference among АРОЕ4nс over an average of 8 years’ time
Colored areas indicate regions of significantly faster CMRgl decline in parahippocampus (p=0.002), precuneus (p=0.003), temporal (p=0.0001), and thalamus (p=0.0007) regions (uncorrected threshold of p=0.005) for BDNF Met than ßD/VF Val/Val among АРОЕ4 carriers, as compared to BDNF Met versus BDNF Val/Val groups among АРОЕ4 non-carriers, over an average of 8 years’ time.