Table 1.
Entire Cohort (n=114) Demographics
| Baseline Characteristics | APOE4c/BDNF Met (N=20) | APOE4c/BDNF Val/Val (N= 39) | APOE4nc/BDNF Met (N=20) | APOE4nc/BDNF Val/Val (N= 35) | APOE4 effect p-value | BDNF effect p-value | APOE4×BDNF p-value |
|---|---|---|---|---|---|---|---|
| Sex male/female, (%) | 6/14 (30%/70%) | 14/25 (35.9%/64.1%) | 11/9 (55%/45%) | 12/23 (34.3%/65.7%) | 0.11 | 0.65 | 0.17 |
| APOE4 (HM/HT/NC) | 11/9/0 | 12/27/0 | 0/0/20 | 0/0/35 | NA | NA | NA |
| Education, years mean (SD) | 16.1 (1.8) | 15.5 (2.1) | 58.3 (4.2) | 57.0 (4.5) | 0.25 | 0.31 | 0.58 |
| Age, years mean (SD) | 55.0 (4.0) | 56.8 (4.5) | 16.3 (2.1) | 16.1 (2.1) | 0.18 | 0.70 | 0.07 |
| MMSE mean (SD) | 29.6 (0.7) | 29.9 (0.4) | 29.7 (0.7) | 29.6 (0.7) | 0.16 | 0.21 | 0.18 |
| AVLT STM mean (SD) | 10.6 (2.8) | 10.1 (2.7) | 8.3 (1.9) | 9.5 (2.5) | 0.01* | 0.42 | 0.07 |
| AVLT LTM mean (SD) | 9.9 (3.4) | 9.8 (2.5) | 7.3 (2.5) | 8.9 (3.1) | 0.01* | 0.17 | 0.12 |
| AVLT TL mean (SD) | 51.3 (9.5) | 48.6 (7.7) | 43.9 (5.8) | 47.0 (8.8) | 0.02* | 0.86 | 0.07 |
| COWAT mean (SD) | 45.8 (10.3) | 44.9 (12.0) | 43.6 (9.3) | 43.4 (10.3) | 0.39 | 0.82 | 0.88 |
| Diabetes n (%) | 0 | 1 (2.6%) | 0 | 0 | 1.00 | 1.00 | 1.00 |
| Hypertension n (%) | 3 (15.0%) | 11 (28.2%) | 2 (10.0%) | 3 (8.6%) | 0.65 | 0.27 | 0.41 |
| Smoking n (%) | 3 (15.0%) | 7 (17.9%) | 6 (30.0%) | 10 (28.6%) | 0.26 | 0.78 | 0.77 |
| Hyperlipidemia n (%) | 3 (15.0%) | 11 (28.2%) | 2 (10.0%) | 3 (8.6%) | 0.38 | 0.24 | 0.05 |
| Any cardiovascular n (%) | 0 | 1 (2.6%) | 0 | 0 | 1.00 | 1.00 | 1.00 |
Abbreviations: APOE4 HM: apolipoprotein e4 homozygote, APOE4/4; APOE4 HT: apolipoprotein e4 heterozygote, APOE3/4; APOE4 NC: apolipoprotein e4 non-carrier, APOE 3/3, 2/3; MMSE: Mini-Mental State Examination; AVLT: Auditory-Verbal Learning Test; STM: short term memory; LTM: long term memory; TL: total learning; COWAT: Controlled Oral Word Association Test. Note: COWAT tests executive function and language skills, on a scale with a lower limit of 0 and no upper limit, with higher scores indicating better performance. Data are given as mean +/‒ standard deviation unless otherwise indicated, p-values for continuous variables are from two-way ANOVA and p-values for categorical data are from logistics regression test as developed and reported in Hosmer & Lemeshow, 1989.[44]