Table 2.
PiB-PET Cohort (N=58) Demographics
| Baseline Characteristics | APOE4c/BDNF Met (N=14) | APOE4c/BDNF Val/Val (N= 20) | APOE4nc/BDNF Met (N=10) | APOE4nc/BDNF Val/Val (N= 14) | APOE4 effect p-value | BDNF Met effect p-value | APOE4×BDNF p-value |
|---|---|---|---|---|---|---|---|
| Sex male/female, (%) | 4/10 (28.6%/71.4%) | 8/12 (40%/60%) | 3/7 (30%/70%) | 5/9 (35.7%/64.3%) | 0.94 | 0.49 | 0.83 |
| APOE4 (HM/HT/NC) | 8/6/0 | 5/15/0 | 0/0/10 | 0/0/14 | NA | NA | NA |
| Education, years mean (SD) | 15.8 (1.6) | 15.7 (2.3) | 16 (2.3) | 15.7 (2.5) | 0.78 | 0.87 | 0.87 |
| Age, years mean (SD) | 55.3 (5.5) | 57.4 (4.4) | 57.1 (5.3) | 57.5 (4.1) | 0.28 | 0.56 | 0.43 |
| MMSE mean (SD) | 29.6 (0.8) | 29.8 (0.4) | 29.7 (0.7) | 29.6 (0.7) | 0.64 | 0.96 | 0.50 |
| AVLT STM mean (SD) | 10.3 (2.9) | 9.4 (3.1) | 8.8 (2) | 9.6 (2.4) | 0.79 | 0.55 | 0.24 |
| AVLT LTM mean (SD) | 9.6 (3.5) | 8.8 (3.3) | 9 (2.4) | 9.4 (2.9) | 0.69 | 0.89 | 0.49 |
| AVLT TL mean (SD) | 51.8 (9.3) | 46.5 (9.5) | 46.7 (7.8) | 48.3 (8.3) | 0.30 | 0.66 | 0.16 |
| COWAT mean (SD) | 43.9 (7.1) | 46.7 (11.4) | 40.6 (7.9) | 48.9 (13.1) | 0.07 | 0.98 | 0.34 |
| Diabetes (%) | 0 | 0 | 0 | 0 | 1.00 | 1.00 | 1.00 |
| Hypertension (%) | 4 (20.0%) | 6 (15.4%) | 0 | 1 (2.9%) | 0.99 | 0.93 | 0.99 |
| Smoking (%) | 4 (20.0%) | 4 (10.3%) | 3 (15.0%) | 1 (2.9%) | 0.94 | 0.56 | 0.40 |
| Hyperlipidemia (%) | 2 (10.0%) | 6 (15.4%) | 3 (15.0%) | 0 | 0.36 | 0.30 | 0.99 |
| Any cardiovascular (%) | 1 (5.0%) | 2 (5.1%) | 1 (5.0%) | 0 | 0.80 | 0.77 | 1.00 |
Abbreviations: APOE4 HM: apolipoprotein e4 homozygote, APOE4/4; APOE4 HT: apolipoprotein e4 heterozygote, APOE3/4; APOE4 NC: apolipoprotein e4 non-carrier, APOE 3/3, 2/3; MMSE: Mini-Mental State Examination; AVLT: Auditory-Verbal Learning Test; STM: short term memory; LTM: long term memory; TL: total learning; COWAT: Controlled Oral Word Association Test. Note: COWAT tests executive function and language skills, on a scale with a lower limit of 0 and no upper limit, with higher scores indicating better performance. Data are given as mean +/‒ standard deviation unless otherwise indicated, p-values for continuous variables are from two-way ANOVA and p-values for categorical data are from logistics regression test as developed and reported in Hosmer & Lemeshow, 1989.[44]