Table 3.
Rate of Cognitive Change over Time from Baseline for Entire Cohort (N=114) and APOE4c (N=59) Subgrouped by BDNF Status
| Total N=114 | Total N=114 | Total N=59 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| APOE4c (N=59) | APOE4nc (N=55) | P-Value | BDNF Met Carrier (N=40) | BDNF Val/Val (N=74) | P-Value | APOE4c/BDNF Met Carrier (N=20) | APOE4c/BDNF Val/Val (N=39) | P-Value | APOE by BDNF P-Value | |
| Time from Baseline, years Mean (SD) | 15 (4.76) | 15.04 (5.69) | 0.97 | 13.93 (5.29) | 15.61 (5.10) | 0.10 | 13.4 (4.76) | 15.82 (4.60) | 0.06 | 0.62 |
| FDG follow up time in years Mean (SD) | 7.34 (3.60) N=50 | 8.56 (3.43) N=46 | 0.09 | 8.31 (3.52) N=32 | 7.73 (3.58) N=64 | 0.45 | 7.26 (3.99) N=17 | 7.38 (3.44) N=33 | 0.91 | 0.33 |
| MMSE (SD) | −0.03 (0.04) | −0.01 (0.04) | 0.06 | −0.03 (0.04) | −0.02 (0.04) | 0.21 | −0.04 (0.05) | −0.02 (0.04) | 0.10 | 0.28 |
| AVLT TL (SD) | −0.45 (0.55) | −0.22 (0.48) | 0.02* | −0.31 (0.58) | −0.36 (0.50) | 0.64 | −0.52 (0.75) | −0.43 (0.44) | 0.65 | 0.22 |
| AVLT STM (SD) | −0.14 (0.22) | −0.04 (0.13) | 0.01* | −0.10 (0.19) | −0.09 (0.18) | 0.72 | −0.17 (0.25) | −0.12 (0.20) | 0.43 | 0.13 |
| AVLT LTM (SD) | −0.17 (0.25) | −0.06 (0.18) | 0.01* | −0.09 (0.21) | −0.12 (0.23) | 0.56 | −0.15 (0.30) | −0.17 (0.23) | 0.86 | 0.08 |
| COWAT (SD) | 0.11 (0.46) | 0.19 (0.50) | 0.34 | 0.16 (0.47) | 0.15 (0.49) | 0.93 | 0.21 (0.61) | 0.08 (0.41) | 0.44 | 0.54 |
| # of subjects who developed incident MCI | 17 | 4 | 0.0004* | 7 | 14 | 0.85 | 6 | 11 | 0.89 | 0.89 |
Table 3: Rate of cognitive change over time from baseline for entire cohort (N=114) and APOE4c (N=59) subgrouped by BDNF status was determined in the framework of linear mixed effects model for each subject who had at least two visits. Abbreviations: APOE4c: apolipoprotein e4 carrier, APOE4/4, 3/4; APOE4nc: apolipoprotein e4 non-carrier, APOE 3/3, 2/3; MMSE: Mini-Mental State Examination; AVLT: Auditory-Verbal Learning Test; STM: short term memory; LTM: long term memory; TL: total learning; COWAT: Controlled Oral Word Association Test. Note: COWAT tests executive function and language skills, on a scale with a lower limit of 0 and no upper limit, with higher scores indicating better performance. Data are given as mean +/‒ standard deviation unless otherwise indicated, p-values were computed under the linear mixed effect modeling with APOE4 and BDNF interaction term (p≤0.05)