Figure 3.

Gut β-glucuronidase is emerging as a new therapeutic target in the improvement of menopausal disorders such as menopausal syndrome, as well as in the prevention and treatment of gynecological cancers. As for improving menopausal symptoms, the composition and diversity of the gut microbiota can be normalized through the intake of dietary fiber, herbal nutrients, and beneficial gut microbiota, and by increasing the bioavailability of estrogenic agents, such as soy isoflavones, which can be converted into efficiently absorbed estradiol. In the prevention and treatment of gynecological cancers, by inhibiting gmGUS enzyme activity and reducing the level of biologically active estrogens, and reducing the intestinal side effects of anti-cancer drugs, which exerts a synergistic effect and suppress the progression of gynecological cancers.