Table 3.
Comparison of AI-based BRAF mutation prediction with confirmed PCR result based on specific histomorphological features. Shown in brackets is the number of cases where the PCR result matched the AI result. Abbreviations: SE: sensitivity; SP: specificity; stand: standard.
| AI Prediction | No. Cases | |||
|---|---|---|---|---|
| Quality | High | Stand | Poor | |
| BRAF positive | 28 (24) | 8 (7) | 14 (9) | |
| BRAF negative | 6 (3) | 11 (3) | 29 (11) | |
| SE [%]: 89 | SE [%]: 47 | SE [%]: 33 | ||
| SP [%]: 43 | SP [%]: 75 | SP [%]: 69 | ||
| Urothelial differentiation | Present | Absent | ||
| BRAF positive | 42 (34) | 8 (6) | ||
| BRAF negative | 8 (2) | 38 (15) | ||
| SE [%]: 85 | SE [%]: 21 | |||
| SP [%]: 20 | SP [%]: 88 | |||
| Invasive tumour front | Present | Absent | ||
| BRAF positive | 10 (8) | 19 (16) | ||
| BRAF negative | 24 (9) | 4 (1) | ||
| SE [%]: 35 | SE [%]:84 | |||
| SP [%]: 82 | SP [%]: 25 | |||
| Inflammation | Present | Absent | ||
| BRAF positive | 11 (8) | 39 (32) | ||
| BRAF negative | 28 (8) | 17 (9) | ||
| SE [%]: 29 | SE [%]: 80 | |||
| SP [%]: 73 | SP [%]: 56 | |||