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Hurdles to successful immunotherapy in rGBM. The blood–brain barrier (BBB), glioma heterogeneity, glioma-associated microglia/myeloid cells, and T cell suppression are established features in GBM that are anticipated to resist immunotherapy. See Section 3.6 for discussion. MDSCs = Myeloid Derived Suppressor Cells, PMN—polymorphonuclear leukocytes, MGMT = O-6-mehtyguanine-DNA methyltransferase; CAR = Chimeric Antigen Receptor.
