Table 3.
Associations of fluctuations in biomarkers of inflammation with sleep and physical activity among patients with gynecologic cancer treated with chemotherapy and noncancer controls.
| Variable | Moderate to Vigorous Activity | |||||||
|---|---|---|---|---|---|---|---|---|
| IL-10 | IL-1β | TNF-α | TNFR1 | TNFR2 | CRP | IL-6^ | IL-1Ra^ | |
| Intercept | 1.76 *** | 1.84 *** | 1.85 *** | 1.72 *** | 1.86 *** | 1.90 *** | 1.81 *** | 1.75 *** |
| Group | −0.46 *** | −0.70 *** | −0.73 *** | −0.52 ** | −0.68 *** | −0.61 *** | −0.57 *** | −0.59 *** |
| Between-person variance in cytokine | 2.91 × 10−3 | −6.91 × 10−3 | −8.71 × 10−3 | 5.26 × 10−4 | −8.00 × 10−5 | −0.03 | 0.04 | 7.88 × 10−3 |
| Within-person variance in cytokine | 2.46 × 10−3 | −1.66 × 10−3 | −1.77 × 10−3 | −2.00 × 10−5 | 1.90 × 10−5 | 1.45 × 10−3 | −0.01 | 0.02 |
| Group × between-person variance in cytokine | −5.37 × 10−3 | 0.04 | 0.01 | −4.20 × 10−4 | 1.05 × 10−4 | 0.02 | −0.02 | 0.02 |
| Group × within-person variance in cytokine | 7.24 × 10−3 * | 7.34 × 10−3 | −8.89 × 10−3 | 8.10 × 10−5 | 2.00 × 10−5 | −7.70 × 10−3 | −0.01 | −0.04 |
| Variable | Light Activity | |||||||
| IL-10 | IL-1β | TNF-α | TNFR1 | TNFR2 | CRP | IL-6^ | IL-1Ra^ | |
| Intercept | 3.14 *** | 3.19 *** | 3.15 *** | 2.79 *** | 2.93 *** | 3.20 *** | 3.04 *** | 3.05 *** |
| Group | −0.75 *** | −0.79 *** | −0.48 | −0.05 | −0.20 | −0.51 ** | −0.50 *** | −0.42 * |
| Between-person variance in cytokine | −6.05 × 10−3 | −0.03 | −0.02 | 1.12 × 10−3 | 4.00 × 10−5 | −0.05 | −0.07 | −0.04 |
| Within-person variance in cytokine | −6.55 × 10−3 | −0.04 * | −0.02 * | −3.80 × 10−4 | −1.10 × 10−4 | −8.12 × 10−3 | −0.08 * | −0.03 |
| Group × between-person variance in cytokine | 0.01 | 0.09 | 5.36 × 10−3 | −2.44 × 10−3 | −2.50 × 10−4 | 0.03 | 0.06 | −3.37 × 10−3 |
| Group × within-person variance in cytokine | 5.51 × 10−3 | 0.06 * | 3.78 × 10−3 | −1.16 × 10−3 | −9.00 × 10−5 | −0.04 | 0.06 | −2.12 × 10−3 |
| Variable | Sedentary Time | |||||||
| IL-10 | IL-1β | TNF-α | TNFR1 | TNFR2 | CRP | IL-6^ | IL-1Ra^ | |
| Intercept | 10.86 *** | 10.81 *** | 10.55 *** | 11.26 *** | 11.02 *** | 10.72 *** | 10.99 *** | 10.97 *** |
| Group | 0.63 | 0.91 * | 1.28 * | 7.05 × 10−3 | 0.37 | 0.29 | 0.42 | 0.28 |
| Between-person variance in cytokine | −1.34 × 10−3 | 0.02 | 0.04 * | −1.91 × 10−3 | −7.00 × 10−5 | 0.06 | 0.06 | 6.91 × 10−4 |
| Within-person variance in cytokine | 0.01 * | 0.05 | 6.83 × 10−3 | 1.13 × 10−3 | 1.17 × 10−4 | −0.01 | 0.04 | 7.44 × 10−3 |
| Group × between-person variance in cytokine | −4.13 × 10−3 | −0.12 | −0.06 | 3.20 × 10−3 | 1.48 × 10−4 | 0.02 | 3.76 × 10−3 | 0.05 |
| Group × within-person variance in cytokine | 8.95 × 10−4 | −0.02 | 2.26 × 10−4 | −1.96 × 10−3 | −6.60 × 10−4 | 0.09 * | 0.05 | 0.15 |
| Variable | Wake after Sleep Onset | |||||||
| IL-10 | IL-1β | TNF-α | TNFR1 | TNFR2 | CRP | IL-6^ | IL-1Ra^ | |
| Intercept | 1.50 *** | 1.46 *** | 1.38 *** | 1.42 *** | 1.45 *** | 1.35 *** | 1.49 *** | 1.50 *** |
| Group | 0.49 ** | 0.53 ** | 0.59 ** | 0.51 ** | 0.42 | 0.51 *** | 0.44 *** | 0.68 *** |
| Between-person variance in cytokine | −2.00 × 10−4 | 1.99 × 10−4 | 9.05 × 10−3 | 3.39 × 10−4 | 7.30 × 10−5 | 0.03 | −8.63 × 10−3 | −0.01 |
| Within-person variance in cytokine | −2.96 × 10−3 | −1.22 × 10−3 | −6.25 × 10−3 | −4.10 × 10−4 | −6.00 × 10−5 | 1.72 × 10−3 | −0.01 | −0.05 |
| Group × between-person variance in cytokine | −2.88 × 10−3 | −0.03 | −0.01 | −5.30 × 10−4 | −9.88 × 10−6 | −0.03 | −0.14 | −0.12 |
| Group × within-person variance in cytokine | −1.88 × 10−3 | 0.03 | 8.23 × 10−3 | 4.00 × 10−5 | 1.35 × 10−4 | −1.04 × 10−3 | 0.04 | −0.01 |
| Variable | Sleep Efficiency | |||||||
| IL-10 | IL-1β | TNF-α | TNFR1 | TNFR2 | CRP | IL-6^ | IL-1Ra^ | |
| Intercept | 0.80 *** | 0.80 *** | 0.82 *** | 0.81 *** | 0.81 *** | 0.84 *** | 0.81 *** | 0.81 *** |
| Group | −0.04 * | −0.03 | −0.05 * | −0.03 | −0.03 | −0.04 * | −0.04 ** | −0.08 *** |
| Between-person variance in cytokine | 4.70 × 10−4 | 1.03 × 10−3 | −1.34 × 10−3 | −2.00 × 10−5 | −2.00 × 10−5 | −4.96 × 10−3 | 3.93 × 10−3 | −1.02 × 10−3 |
| Within-person variance in cytokine | −5.20 × 10−4 | −3.78 × 10−3 | −1.92 × 10−3 * | 9.00 × 10−5 | 1.90 × 10−5 | −1.97 × 10−3 | −7.81 × 10−3 | −2.32 × 10−3 |
| Group × between-person variance in cytokine | 2.04 × 10−4 | 9.06 × 10−4 | 1.53 × 10−3 | 7.50 × 10−6 | 1.54 × 10−6 | 3.90 × 10−3 | 9.58 × 10−3 | 0.02 * |
| Group × within-person variance in cytokine | 8.70 × 10−4 | 3.99 × 10−3 | 5.50 × 10−4 | −1.40 × 10−4 | −3.00 × 10−5 | 3.41 × 10−3 | 5.32 × 10−3 | 0.01 |
Analyses controlled for age, education, comorbidities, and menopausal status. IL-6^ and IL-1Ra^ were natural log-transformed. *** = p < 0.001; ** = p < 0.01; * = p < 0.05.