Table 4.

Univariate and multivariable analysis: subhazards ratio (sub-HR) of mortality estimated by Fine and Gray model (n = 172). Bold numbers correspond to statistically significant values.

Variable	Univariate Sub-HR	95% CI	Multivariable Sub-HR	95% CI
Sex
Male	1.00	ref	1.00	ref
Female	0.70	0.46,1.06	0.96	0.58,1.60
Body site
Head/Neck	0.41	0.18,0.91	1.11	0.53,2.33
Trunk	1.00	ref	1.00	ref
Arms	0.47	0.23,0.96	0.52	0.23,1.21
Legs	0.44	0.27,0.74	0.59	0.29,1.19
Breslow score (unit increase)	2.90	1.00,8.43	2.46	0.60,10.10
Ulceration
No	1.00	ref	1.00	ref
Yes	1.68	0.91,3.11	1.73	0.79,3.75
Histological subtype
SSM	1.00	ref	1.00	ref
LMM	0.34	0.11,1.06	0.43	0.09,2.08
NM	1.11	0.50,2.44	1.11	0.34,3.61
ALM	1.44	0.54,3.83	2.18	0.58,8.10
Sentinel lymph node
No	1.00	ref	1.00	ref
Yes	1.00	0.61,1.63	0.84	0.42,1.67
Type of first progression
Local	1.00	ref	1.00	ref
Nodal	1.33	1.69,8.47	3.13	1.37,7.15
Distant	2.10	3.40,19.81	2.73	1.28,5.81
Type of second progression
None	1.00	ref	1.00	ref
Local	3.93	1.65,9.34	5.78	2.56,13.06
Nodal	14.19	8.28,24.31	9.89	5.41,18.07
Distant	12.05	6.48,22.38	8.67	4.55,16.52
Type of third progression
None	1.00	ref	1.00	ref
Local	0.85	0.13,5.68	0.68	0.19,2.43
Nodal	3.73	2.53,5.49	1.43	0.81,2.51
Distant	3.66	2.01,6.68	2.51	1.29,4.89
Age at diagnosis (unit increase)	1.00	0.99,1.02	1.01	0.99,1.03
Elapsed time between diagnosis and first progression (years)
[0–1)	1.00	ref	1.00	ref
[1–2)	1.05	0.45,2.48	1.29	0.54,3.07
[2–3)	1.78	0.81,3.93	1.35	0.53,3.46
3+	1.29	0.70,2.38	1.34	0.61,2.91