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. 2023 Jul 26;12(15):1937. doi: 10.3390/cells12151937

Figure 2.

Figure 2

Tr-OxPLs induce more severe lung injuries in old mice. (A) Young mice were challenged with indicated Tr-OxPL species (i.v., 10 mg/kg, 24 h) followed by measurement of total cell and protein content in BAL; n = 6, * p < 0.05. (B–D) Young and old mice were exposed to KOdiA-PC or Paz-PC (10 mg/kg, 24 h). (B) Total cell and protein content in BAL; n = 6, * p < 0.05 vs. Vehicle, ** p < 0.05 vs. young group. (C) Evans blue extravasation assay to evaluate lung vascular leak. Shown are representative images of six independent experiments. (D) PCLS obtained from young and old mice were treated with KOdiA-PC in organotypic culture (40 µg/mL, 6 h), and qPCR was performed to measure the mRNA transcript levels of indicated proinflammatory genes; n = 3, * p < 0.05 vs. Vehicle, ** p < 0.05 vs. young group.