Table 3.

Summary of the behavioral effects of the Fmr1-KO genotype and CBDV treatments.

Behavioral Domain	Test	Variable Measured	ADULTS (Study 1)			JUVENILES (Study 2)
			Figures	KO Genotype Effect	CBDV Treatment Effect	Figures	KO Genotype Effect	CBDV Treatment Effect
Anxiety	EPM	% Time open arms	Figure S1	none	none	Figure S2	↓ anxiety	none
	OF	%Time center	Figure 2b	↓ anxiety in CBDV-100 only	CBDV-100 induces a KO phenotype	Figure 5b	↓ anxiety	none
Locomotor activity	EPM	total arm entries	Figure S1	none	none	Figure S3	↑ activity	none
	OF	Total distance moved	Figure 2a	↑ activity	none	Figure 5a	↑ activity	none
Learning & memory	OR	% OR index	Figure 2d	↓ object memory	↓ in WT mice, no rescue in KOs	Figure 5d	↓ object memory	↓ in WT mice, rescue in KOs
Social interest	3-COMP	% sociability index (trial 2)	Figure 3d	none	none	Figure 6d	none	none
		% social novelty index (trial 3)	Figure 3f	↓ social novelty preference	↓ in WT mice, no rescue in KOs	Figure 6f	↓ social memory	↓ in WT mice, rescue in KOs
	SI	Affiliation time	Figure 4a	↓ social interaction	↓ in WT mice, no rescue in KOs	Figure 7a	↓ social interaction	↓ in WT mice, rescue in KOs
Sensory responsiveness	ASR	startle body response	Figure 4b	↑ acoustic startle	rescue in KOs only with CBDV-20	Figure 7b	↑ acoustic startle	rescue in KOs

Significant genotype x treatment interactions are highlighted in blue. EPM = elevated plus maze; OF = open field; OR = object recognition; 3-COMP = 3-compartment test; SI = social interaction; ASR = acoustic startle response. ↑ increase. ↓ decrease.