Table 1. Common genes in early onset Alzheimer’s disease.

Genes	Function of protein*	Pathway of disease	Inheritance	Chromosomal location†
PSEN1	Subunit of gamma-γ-secretase complex; integral membrane protein processing	AβPP Metabolism	AD	14q24.2
PSEN2	Subunit of gamma-γ-secretase complex; integral membrane protein processing	AβPP Metabolism	AD	1q42.13
APP	Transmembrane protein; neural growth and repair	AβPP Metabolism	AD	21q21.3

Abbreviations: PSEN1: presenin 1; PSEN2: presenin 2; APP: amyloid precursor protein; AD: autosomal dominant; AβPP: amyloid-β protein precursor.

^* https://www.genecards.org/

^† https://omim.org/entry/