Table 3. Average gene coverage and sequencing depth expected in sequencing for Alzheimer’s disease genes.
| Genes | Average coverage (%) | Average depth |
|---|---|---|
| APP | 100 | 105.73 |
| PSEN1 | 98.89 | 111.32 |
| PSEN2 | 100 | 110.2 |
| APOE | 100 | 92.4 |
| BIN1 | 100 | 121.66 |
| CR1 | 62.73 | 70.58 |
| CLU | 100 | 119.45 |
| ABCA7 | 100 | 117.71 |
| PICALM | 93.12 | 83.1 |
| TREM2 | 100 | 123.81 |
| SORL1 | 99.88 | 101.53 |
| ADAM10 | 96.01 | 83.47 |
| CD2AP | 93.58 | 80.23 |
| MS4A6A | 99.74 | 101.22 |
| EPHA1 | 100 | 123.04 |
| GRID2IP | 99.79 | 113.99 |
| GRN | 100 | 139.3 |
| MAPT | 100 | 185.73 |
| C9ORF72 | 96.79 | 76.9 |
| NOTCH3 | 99.77 | 151.88 |
| PLCG2 | 99.86 | 127.72 |
| PLD3 | 100 | 113.51 |
| ACE | 99.91 | 112.06 |
| WDR76 | 99.87 | 106.15 |
| VWA2 | 100 | 127.97 |
| MUC6 | 100 | 374.11 |
| SHARPIN | 100 | 132.06 |
Abbreviations: APP: Amyloid Beta A4 Precursor Protein; PSEN1: Presenilin 1; PSEN2: Presenilin 2; APOE: Apolipoprotein E; BIN1: Bridging Integrator 1; CR1: Complement Component Receptor 1; CLU: Clusterin; ABCA7: ATP-Binding Cassette, Subfamily A, Member 7; PICALM: Phosphatidylinositol-Binding Clathrin Assembly Protein; TREM2: Triggering Receptor Expressed on Myeloid Cells 2; SORL1: Sortilin-Related Receptor; ADAM10: A Disintegrin And Metalloproteinase Domain 10; CD2AP: CD2-Associated Protein; MS4A6A: Membrane-Spanning 4-Domains, Subfamily A, Member 6A; EPHA1: Ephrin Receptor EphA1; GRID2IP: GRID2-Interacting Protein 1; GRN: Granulin Precursor; MAPT: Microtubule-Associated Protein TAU; C9ORF72: Chromosome 9 Open Reading Frame 72; NOTCH3: Notch Receptor 3; PLCG2: Phospholipase C, Gamma-2; PLD3: Phospholipase D Family, Member 3; ACE: Angiotensin I-Converting Enzyme; WDR76: WD Repeat-Containing Protein 76; VWA2: Von Willebrand Factor A Domain-Containing Protein 2; MUC6: Mucin 6, Gastric; SHARPIN: Shank-Associated RH Domain Interactor.