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. 2023 Jul 31;12(15):1972. doi: 10.3390/cells12151972

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Leucine-rich repeat kinase 2 (LRRK2) acts as a central hub that interacts with numerous molecules, such as Rab family proteins, vacuolar protein sorting protein (VPS), Golgi outposts and Golgi posts (GOPs), cyclin-dependent kinase 5 (CDK5), Ppotein kinase C (PKC), and synapse-associated protein 97 (SAP97), among others. These interactions impact trans-Golgi network membrane transport and Golgi morphology which ultimately contribute to the development of pathological features associated with Parkinson’s disease (PD).