. 2023 Jun 16;12(14):15632–15649. doi: 10.1002/cam4.6123

TABLE 1.

Univariate and multivariate analyses of factoring affecting the OS of patients with CC based on Cox proportional hazards models including the expression of glycolytic genes explored with the HG‐1.0 ST microarray and FIGO clinical stage.

Covariates	n	Univariate analysis ^g			Multivariate analysis ^h
Covariates	n	HR ^d	95% CI	p ^e	HR ^b	95% CI	p ^e
FIGO
≤IIA	29	1.0			1.0
≥IIB	32	3.4	1.1–10.4	3.6 × 10⁻²	3.3 ^d	1.1–9.6 ^d	3.5 × 10⁻² ^f
Glycolytic gene expression profile
FC <1.98 ^a	57	1.0			1.0
FC≥1.98	4	8.6	2.7–28.0	3.2 × 10⁻⁴	5.8	1.7–20.2	5.0 × 10⁻³
Glycolysis FC score ^b	61	5.0	1.1–22.3	3.6 × 10⁻²	3.2	1.0–14.5	1.2 × 10⁻²
LDHA
Low ^c	40	1.0			1.0
High	21	3.1	1.1–8.3	2.7 × 10⁻²	3.0	1.1–8.19	2.9 × 10⁻²
PFKP
Low	32	1.0			1.0
High	29	3.5	1.1–10.9	3.0 × 10⁻²	3.4	1.1–10.5	3.5 × 10⁻²
TPI1P1
Low	52	1.0			1.0
High	9	3.7	1.3–10.9	1.5 × 10⁻³	2.6	0.8–7.87	4.0 × 10⁻²
GAPDH
Low	54	1.0			1.0
High	7	5.6	1.9–16.3	2.0 × 10⁻³	4.0	1.3–12.3	5.2 × 10⁻²
GPI
Low	19	1.0			1.0
High	42	8.5	1.1–64.1	3.9 × 10⁻²	7.9	1.0–60.0	5.6 × 10⁻²
ENO
Low	21	1.0			1.0
High	40	9.2	1.2–69.5	3.2 × 10⁻²	7.3	0.9–56.4	5.6 × 10⁻²
PGK1
Low	44	1.0			1.0
High	17	2.8	1.0–7.6	3.7 × 10⁻²	2.3	0.9–6.2	1.1 × 10⁻¹
ALDOA
Low	15	1.0			1.0
High	46	5.8	0.7–44.3	8.7 × 10⁻²	4.9	0.6–37.6	1.2 × 10⁻¹

Abbreviations: CI, confidence interval; FIGO stage, International Federation of Gynecology and Obstetrics stage; HR, hazard ratio.

^{^a}

Optimal cutoff values were selected according to the ROC curve of the glycolysis FC score.

^{^b}

The analysis was performed considering the glycolysis FC score as continuous variable.

^{^c}

Optimal cutoff values were selected according to the ROC analysis in relation to fold changes in genes expression obtained with the Human Gene 1.0 ST microarray.

^{^d}

Adjusted hazard ratio.

^{^e}

Cox proportional hazards model.

^{^f}

These calculations were obtained in the multivariate analysis performed with LDHA. The values of FIGO obtained in the multivariate analysis with the other markers are not shown but are similar to these values.

^{^g}

Univariate analysis was performed considering one variable for the analysis.

^{^h}

Multivariate analysis was performed considering gene expression and FIGO stage for the analysis.