Table 2.

Sum up of Macdonald criteria and RANO criteria.

Response	Macdonald Criteria	RANO Criteria
Complete response	All: complete disappearance of all enhancing measurable and non-measurable diseases sustained for at least 4 weeks; no new lesions; no corticosteroids; being stable or improved clinically	All: T1-gadolinium enhancing disease: none; T2w/FLAIR: stable or decreasing; new lesion: none; corticosteroid: none; clinical status: stable or improving
Partial response	All: 50% or more decrease in all measurable enhancing lesions sustained for at least 4 weeks; no new lesions; stable or reduced corticosteroid dose; being stable or improved clinically	All: T1-gadolinium enhancing disease: ≥50% decrease; T2w/FLAIR: stable or decreasing; new lesions: none; corticosteroids: stable or decreasing; clinical status: stable or improving
Stable response	All: being not qualified for complete response, partial response or progression; being stable clinically	All: T1-gadolinium enhancing disease: >50% decrease but <25% increase; T2w/FLAIR: stable or decreasing; new lesions: none; corticosteroids: stable or decreasing; clinical status: stable or improving
Progression	Any: 25% or more increase in enhancing lesions; any new lesion; clinical deterioration	Any: T1-gadolinium enhancing disease: ≥25% increase; T2w/FLAIR; new lesions: yes, corticosteroids: not applicable

Abbreviations: RANO, Response Assessment in Neuro-Oncology; FLAIR, Fluid-attenuated inversion recovery.