Skip to main content
. 2023 Aug 4;12(15):2000. doi: 10.3390/cells12152000

Figure 1.

Figure 1

Nicotinic acetylcholine receptor subunit (nAChRs) in different cancer types. Gene CHRNA1: α1 subunit; gene CHRNA3: α3 subunit; gene CHRNA4: α4 subunit; gene CHRNA5: α5 subunit; gene CHRNA6: α6 subunit; gene CHRNA7: α7 subunit; gene CHRNFAM7A: dupα7 subunit (partially duplicated α7 subunit isoform); gene CHRNA9: α9 subunit; gene CHRNA10: α10 subunit; gene CHRNB2: β2 subunit; gene CHRNB4: β4 subunit. (A) Heat map view of several nicotinic acetylcholine receptor (nAChR) subunit genes in human cancers (figure adapted from the Human Protein Atlas, www.proteinatlas.org; accessed on 1 May 2023). The heat map represents the median values per gene for each cancer type. The CHRNA5 subunit is the most commonly expressed nAChR subunit in all cancer types. (B) CHRNA5 expression levels in different human cancers. Each sample is shown as a circle on the graph, and the median is indicated with a red line. Sequencing data were reported as FPKM (fragments per kilo-base of transcript per million reads mapped). Data were generated by the Cancer Genome Atlas (Pathophysiology of CHRNA5, https://www.proteinatlas.org/ENSG00000169684-CHRNA5/pathology; accessed on 1 May 2023).