FIG. 4.

Hypothesis for the creation of AAV-6 from homologous recombination between AAV-1 and AAV-2. The first line represents the AAV-2 genome, with Rep and Cap sequences demarcated by hatched arrows. The second line represents the AAV-1 genome, with the Rep and Cap sequences depicted as solid arrows. The hypothesis suggests homologous recombination between AAV-2 and AAV-1 at the region of the box containing wavy lines; this region contains a highly homologous sequence of the Rep gene shared by AAV-1 and AAV-2. PA, poly(A). A more detailed illustration of the common region of these three viruses is shown at the bottom. Arrows indicate nucleotides that differ.