FIG. 6.

NAB to AAV-1 and AAV-2 in nonhuman and human primates. Sera were analyzed for neutralizing activity against rAAV-1 and rAAV-2 as described in Materials and Methods. The reciprocal dilution of the NAB was plotted for AAV-2 versus AAV-1. Sera were titrated in sequential twofold dilutions. A titer of 1:20 represents the background (i.e., no detectable NAB). The number next to each datum point represents the total number of animals or humans with a particular NAB profile. In panel A, 33 adolescent rhesus monkeys were analyzed. In panel B, 77 normal human volunteers were evaluated.