Skip to main content
PMC home page
The British Journal of Ophthalmology logoLink to The British Journal of Ophthalmology
. 1989 Jul;73(7):516–521. doi: 10.1136/bjo.73.7.516

Retinal sensitivity in hereditary retinal degeneration in Abyssinian cats: electrophysiological similarities between man and cat.

K Narfström 1, G B Arden 1, S E Nilsson 1
PMCID: PMC1041792  PMID: 2757991

Abstract

The functional and electrophysiological similarities in the changes in the electroretinogram (ERG) of man and cat affected by hereditary retinal degenerative disease were studied. The results of a series of log intensity-amplitude studies in a group of young affected Abyssinian cats were fitted to the Naka-Rushton relationship by means of a mathematical package on the University of London mainframe. The analysis showed that the amplitude of the maximum dark-adapted b-wave was significantly reduced by the end of the period studied but that the value of k, a variable inversely equivalent to retinal sensitivity, was only slightly reduced by the retinal degenerative process. The electrophysiological findings thus are similar to those found in cases of human diffuse dominantly inherited retinitis pigmentosa.

Full text

PDF
521

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aguirre G., Alligood J., O'Brien P., Buyukmihci N. Pathogenesis of progressive rod-cone degeneration in miniature poodles. Invest Ophthalmol Vis Sci. 1982 Nov;23(5):610–630. [PubMed] [Google Scholar]
  2. Aguirre G. Inherited retinal degenerations in the dog. Trans Sect Ophthalmol Am Acad Ophthalmol Otolaryngol. 1976 Jul-Aug;81(4 Pt 1):OP667–OP676. [PubMed] [Google Scholar]
  3. Arden G. B., Carter R. M., Hogg C. R., Powell D. J., Ernst W. J., Clover G. M., Lyness A. L., Quinlan M. P. Rod and cone activity in patients with dominantly inherited retinitis pigmentosa: comparisons between psychophysical and electroretinographic measurements. Br J Ophthalmol. 1983 Jul;67(7):405–418. doi: 10.1136/bjo.67.7.405. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Attwell D. The Sharpey-Schafer lecture. Ion channels and signal processing in the outer retina. Q J Exp Physiol. 1986 Oct;71(4):497–536. [PubMed] [Google Scholar]
  5. Birch D. G., Fish G. E. Rod ERGs in children with hereditary retinal degeneration. J Pediatr Ophthalmol Strabismus. 1986 Sep-Oct;23(5):227–232. doi: 10.3928/0191-3913-19860901-07. [DOI] [PubMed] [Google Scholar]
  6. DOWLING J. E., SIDMAN R. L. Inherited retinal dystrophy in the rat. J Cell Biol. 1962 Jul;14:73–109. doi: 10.1083/jcb.14.1.73. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Duvall J., McKechnie N. M., Lee W. R., Rothery S., Marshall J. Extensive subretinal pigment epithelial deposit in two brothers suffering from dominant retinitis pigmentosa. A histopathological study. Graefes Arch Clin Exp Ophthalmol. 1986;224(3):299–309. doi: 10.1007/BF02143075. [DOI] [PubMed] [Google Scholar]
  8. Faulkner D. J., Kemp C. M. Human rhodopsin measurement using a T.V.-based imaging fundus reflectometer. Vision Res. 1984;24(3):221–231. doi: 10.1016/0042-6989(84)90124-x. [DOI] [PubMed] [Google Scholar]
  9. Hamasaki D. I., Maguire G. W. Physiological development of the kitten's retina: an ERG study. Vision Res. 1985;25(11):1537–1543. doi: 10.1016/0042-6989(85)90124-5. [DOI] [PubMed] [Google Scholar]
  10. Jacobson S. G., Voigt W. J., Parel J. M., Apáthy P. P., Nghiem-Phu L., Myers S. W., Patella V. M. Automated light- and dark-adapted perimetry for evaluating retinitis pigmentosa. Ophthalmology. 1986 Dec;93(12):1604–1611. doi: 10.1016/s0161-6420(86)33522-x. [DOI] [PubMed] [Google Scholar]
  11. Kolb H., Gouras P. Electron microscopic observations of human retinitis pigmentosa, dominantly inherited. Invest Ophthalmol. 1974 Jul;13(7):487–498. [PubMed] [Google Scholar]
  12. LaVail M. M., Sidman R. L. C57BL-6J mice with inherited retinal degeneration. Arch Ophthalmol. 1974 May;91(5):394–400. doi: 10.1001/archopht.1974.03900060406015. [DOI] [PubMed] [Google Scholar]
  13. Lyness A. L., Ernst W., Quinlan M. P., Clover G. M., Arden G. B., Carter R. M., Bird A. C., Parker J. A. A clinical, psychophysical, and electroretinographic survey of patients with autosomal dominant retinitis pigmentosa. Br J Ophthalmol. 1985 May;69(5):326–339. doi: 10.1136/bjo.69.5.326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Massof R. W., Finkelstein D. Two forms of autosomal dominant primary retinitis pigmentosa. Doc Ophthalmol. 1981 Nov;51(4):289–346. doi: 10.1007/BF00143336. [DOI] [PubMed] [Google Scholar]
  15. Mullen R. J., LaVail M. Two types of retinal degeneration in cerebellar mutant mice. Nature. 1975 Dec 11;258(5535):528–530. doi: 10.1038/258528a0. [DOI] [PubMed] [Google Scholar]
  16. Naka K. I., Rushton W. A. The generation and spread of S-potentials in fish (Cyprinidae). J Physiol. 1967 Sep;192(2):437–461. doi: 10.1113/jphysiol.1967.sp008308. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Narfström K. L., Nilsson S. E., Andersson B. E. Progressive retinal atrophy in the Abyssinian cat: studies of the DC-recorded electroretinogram and the standing potential of the eye. Br J Ophthalmol. 1985 Aug;69(8):618–623. doi: 10.1136/bjo.69.8.618. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Narfström K., Nilsson S. E. Progressive retinal atrophy in the Abyssinian cat. Electron microscopy. Invest Ophthalmol Vis Sci. 1986 Nov;27(11):1569–1576. [PubMed] [Google Scholar]
  19. Rodrigues M. M., Wiggert B., Hackett J., Lee L., Fletcher R. T., Chader G. J. Dominantly inherited retinitis pigmentosa. Ultrastructure and biochemical analysis. Ophthalmology. 1985 Aug;92(8):1165–1172. doi: 10.1016/s0161-6420(85)33895-2. [DOI] [PubMed] [Google Scholar]
  20. Sanyal S., Bal A. K. Comparative light and electron microscopic study of retinal histogenesis in normal and rd mutant mice. Z Anat Entwicklungsgesch. 1973 Oct 31;142(2):219–238. doi: 10.1007/BF00519723. [DOI] [PubMed] [Google Scholar]
  21. Vogel M. Postnatal development of the cat's retina. Adv Anat Embryol Cell Biol. 1978;54(4):1–66. [PubMed] [Google Scholar]
  22. Wall P. D. The effect of peripheral nerve lesions and of neonatal capsaicin in the rat on primary afferent depolarization. J Physiol. 1982 Aug;329:21–35. doi: 10.1113/jphysiol.1982.sp014288. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. van Nie R., Iványi D., Démant P. A new H-2-linked mutation, rds, causing retinal degeneration in the mouse. Tissue Antigens. 1978 Aug;12(2):106–108. doi: 10.1111/j.1399-0039.1978.tb01305.x. [DOI] [PubMed] [Google Scholar]

Articles from The British Journal of Ophthalmology are provided here courtesy of BMJ Publishing Group

RESOURCES