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[Preprint]. 2023 Aug 6:2023.08.03.551911. [Version 1] doi: 10.1101/2023.08.03.551911

Fig. 1: Schematic overview of the SpaRx method.

Fig. 1:

a, Concept design of the SpaRx model. With the pharmacogenomic profiles serving as the source data, SpaRx enables to predict the cells’ response to drugs in single-cell spatial transcriptomics data via graph-based adversarial adaptation. b, SpaRx comprises three components (feature extractors, drug-response predictor, and discriminators) to leverage source domain and predict cellular response in target domain.