Skip to main content
[Preprint]. 2023 Aug 5:2023.08.03.551759. [Version 1] doi: 10.1101/2023.08.03.551759

Fig 5. Comparison of significant interactions in CRISPRi-DR and MAGeCK.

Fig 5.

(A) The number of hits (both enriched and depleted) are slightly greater in MAGeCK than in the CRISPRi-DR model. However, both models produce comparable number of significant genes. The outlier point seen in for the scatterplot comparing depleted genes (top) is for VAN D1. The number of genes reported in the CRISPRi-DR model span a shorter range than the number of genes reported in MAGeCK. (B) Precision of significant genes reported by the CRISPRi-DR model. Overall, the precision of both enriched and depleted hits in the CRISPRi-DR model (compared to MAGeCK) are high. There is a greater overlap in depletion hits than enriched hits. The LEVO D10 and LZD datasets had almost no hits in MAGeCK [see Extended Data Fig 2 in (Li, Poulton et al. 2022)]. As a result, they were excluded from the precision analysis.