Table 2:

Ranking of Select Genes using the CRISPRi-DR model in 1 Day pre-depletion of treated libraries.

Drug	Gene	D1 Depletion Ranking	D1 Enrichment Ranking
BDQ	atpA	11	4022
BDQ	atpB	6	4027
BDQ	atpC	51	3982
BDQ	atpD	14	4019
BDQ	atpE	25	4008
BDQ	atpF	9	4024
BDQ	atpG	12	4021
BDQ	atpH	8	4025
BDQ	mmpL5	2	4031
CLR	RVBD3579c	40	3993
CLR	erm(37)	1	4021
EMB	embA	2	4031
EMB	embB	3	4030
EMB	embC	19	4014
INH	inhA	3	4030
INH	ahpC	2	4031
INH	cinA	5	4028
INH	katG	4031	2
INH	ndh	4028	5
INH	mshA	4025	8
LEVO	gyrA	4012	21
LEVO	gyrB	4021	12
LZD	erm(37)	3865	168
LZD	tsnR	4032	1
RIF	rpoB	94	3939
RIF	rpoC	147	3886
STR	RVBD2477c	4021	12
STR	gidB	4022	11

For each drug, the CRISPRi-DR model is run on each gene (using data from D1). The coefficient for the slope of concentration dependence $\left({\beta }_c\right)$ is extracted from the fitted regression and used to rank the genes both in increasing order (for depletion) and inversely (for enrichment). Green reflects results consistent with expectations based on knowledge of known gene-drug interactions