Figure 4.
AS modulated mRNA expression profile in Aβ1-42-induced mice. (A) Volcano plot of differentially expressed genes (DGEs) in AS-treated Aβ1-42-induced mice compared to Aβ1-42-induced mice. (B) Heatmap of DGEs in AS-treated Aβ1-42-induced mice and Aβ1-42-induced mice. (C) Chord diagram illustrates the relationship between the investigated gene and its associated pathway. (D) The mRNA expression level of GADD45b was detected by real-time PCR. (E) The mRNA expression levels of Pcdh17 and Zdhhc15 were detected by real-time PCR. Data are presented as mean ± SEM (n ≥ 3). * p < 0.05, model vs. control; # p < 0.05, AS vs. model.