Table 1.
Demographic and clinical characteristics of patients with KD and MIS-C, whose sera were used in the EC experiment.
| MIS-C | KD | HC *4 | p *5 | ||
|---|---|---|---|---|---|
| n = 7 | n = 5 | n = 3 | |||
| Age, yrs *1 | 10.5 (8.8–12.2) | 1.9 (1.6–3.8) | 5.5 (4.2–7.1) | 0.005 | |
| Male, n (%) | 6 (86) | 3 (60) | 2 (67) | NS | |
| Ethnicity, n (%) | Asian | 0 | 1 (20) | 0 | NS |
| AA | 2 (29) | 0 | 0 | ||
| White | 0 | 1 (20) | 2 (67) | ||
| Hispanic | 4 (57) | 2 (40) | 1 (33) | ||
| >2 races | 1 (14) | 1 (20) | 0 | ||
| Illness day of serum collection *2 | 3 (3–4.5) | 5 (4–5) | 418 (416–704) | NS | |
| Coronary artery Zmax *3 | 2.1 (1.6–2.7) | 3.2 (1.7–3.3) | NA | NS | |
| EF min, % | 58 (46–62) | 61 (58–66) | NA | NS | |
| Laboratory data | WBC, 103/uL | 6.5 (5.0–11.1) | 18.4 (12.3–20.7) | NA | 0.048 |
| PLT, 103/mm3 | 140 (93–221) | 358 (181–361) | NA | NS | |
| ESR, mm/h | 44 (36.5–53.5) | 48 (42–58) | NA | NS | |
| CRP, mg/dL | 21.3 (20.3–26.5) | 7.0 (4.8–8.8) | NA | 0.048 | |
| Troponin max, ng/mL | 0.050 (0.015–0.225) | ND | NA | NA | |
*1: median (interquartile range (IQR)) unless specified. *2: Illness Day 1= first day of fever. *3: Maximum Z score (internal diameter normalized for body surface area) for the right and left anterior descending coronary arteries. *4: Late convalescent sera (illness day 414–990 days) from healthy children with a remote history of KD and with always normal coronary arteries by echocardiography, *5: p-values calculated by Mann–Whitney test for continuous variables between two groups (MIS-C vs. KD) and Fisher’s exact test for categorical variables. AA: African American, EFmin: the lowest ejection fraction (EF) level during hospitalization, WBC: white blood cell count, PLT: platelet count, ESR: erythrocyte sedimentation rate, CRP: C-reactive protein, Troponin max: the highest troponin level during hospitalization. ND: not done, NA: not applicable, NS: not significant.