Skip to main content
[Preprint]. 2023 Aug 3:rs.3.rs-3168149. [Version 1] doi: 10.21203/rs.3.rs-3168149/v1

Figure 4: Dexamethasone has discordant effects on cell type specific gene expression in lung and peripheral blood that are reproducible in external datasets.

Figure 4:

a,b, Net enrichment scores from gene set enrichment analysis in blood (a) and lung (b), faceted by cell type. Orange circles have a positive net enrichment score (NES), indicating the pathway is more highly expressed in dexamethasone-treated COVID-19 patients (Dex) or healthy controls relative to NoDex subjects. Solid circles identify pathways where GSEA FDR < 0.1, empty circles identify pathways with GSEA FDR ≥ 0.1, and blank spaces indicate no GSEA NES score was calculated for that pathway. Datasets represented are from COMET (whole blood, TA), Sinha et al (blood) and Liao et al (BAL).