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. 2023 Jul 28;24(15):12139. doi: 10.3390/ijms241512139

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Venn diagram showing total number of proteins detected in both 2D and 3D sample groups as well as the total number of proteins that were detectable in 2D sample group and were not in the 3D sample group and all proteins that were detectable in 3D sample group that were not detected in the 2D sample group; (b) Volcano plot showing total number of proteins detected with increase or decrease in abundance in 3D samples compared to 2D samples. Blue dots represent proteins that have increased in abundance by >1.5 fold with a p-value of <0.05 in 3D samples compared to 2D samples; red dots proteins that have decreased in abundance > 1.5 fold with a p-value of <0.05 in 3D samples compared to 2D samples. Gray are all non-significant detected proteins.

(a) Venn diagram showing total number of proteins detected in both 2D and 3D sample groups as well as the total number of proteins that were detectable in 2D sample group and were not in the 3D sample group and all proteins that were detectable in 3D sample group that were not detected in the 2D sample group; (b) Volcano plot showing total number of proteins detected with increase or decrease in abundance in 3D samples compared to 2D samples. Blue dots represent proteins that have increased in abundance by >1.5 fold with a p-value of <0.05 in 3D samples compared to 2D samples; red dots proteins that have decreased in abundance > 1.5 fold with a p-value of <0.05 in 3D samples compared to 2D samples. Gray are all non-significant detected proteins.