Table 1.

The chemical structures of synthetic MMP-9 inhibitors with their IC₅₀/EC₅₀ values. All chemical structures were produced using ChemDraw version 7.

Inhibitor	Cell Line	IC50/EC50	Chemical Structure
Compound 1 [79]	4T1 cells	EC50 = 139 µM
Compound 2 [79]	4T1 cells	EC50 = 125 µM
Compound 3 [79]	4T1 cells	EC50 = 132 µM
Compound 4 [80]	MCF-7	IC50 = 6.9 ± 0.5 nM
	NFS-60	IC50 = 5.5 ± 0.6 nM
	HepG-2	IC50 = 3.1 ± 0.4 nM
Compound 5 [80]	MCF-7	IC50 = 3.6 ± 0.4 nM
	NFS-60	IC50 = 3.61 ± 0.1 nM
	HepG-2	IC50 = 2.2 ± 0.1 nM
Compound 6 [80]	MCF-7	IC50 = 6.6 ± 0.7 nM
	NFS-60	IC50 = 5.8 ± 0.2 nM
	HepG-2	IC50 = 5.7 ± 1 nM
Compound 7 [81]	HCT116	IC50 = 7.403 ± 0.201 nM
Compound 8 [82]	MDA-MB231	IC50 = 3.8 ± 0.7 nM
	Caco-2	IC50 = 3.3 ± 0.5 nM