AKT	Protein kinase B (PKB)
APC	Adenomatous polyposis coli
BRAF	v-Raf murine sarcoma viral oncogene homolog B1
CAR-T	Chimeric antigen receptor (CAR) T-cell
CDK	Cyclin-dependent kinase
CI	Confidence interval
c-MET	c-Mesenchymal-epithelial transition factor
CNS	Central nervous system
CRC	Colorectal cancer
DCC	Deleted in colorectal cancer
DCR	Disease control rate
DoR	Duration of response
EGFR	Epidermal growth factor receptor
EMA	European Medicines Agency
ERK	Extracellular signal-regulated kinase
FAK	Focal adhesion kinase
FDA	Food and Drug Administration
FGFR	Fibroblast growth factor receptor
FOX	Forkhead box
FTI	Farnesyl transferase inhibitors
GDP	Guanosine diphosphate
GRB7	Growth factor receptor-bound protein 7
GTP	Guanosine triphosphate
HLA	Human leukocyte antigens
HR	Hazard ratio
HRAS	Harvey rat sarcoma viral oncogenes
ICIs	Immune checkpoint inhibitors
IV	Intravenous
JAK	Janus kinase
JNK	c-Jun N-terminal kinase
KRAS	Kirsten rat sarcoma
MAPK	Mitogen-activated protein kinase
MEF	Mouse embryonic fibroblast
MEK	Mitogen-activated protein kinase
mTOR	Mammalian target of rapamycin
MYC	Master regulator of cell cycle entry and proliferative metabolism
NE	Not evaluable
NF-κB	Nuclear factor-kappa B
NR	Not reached
NRAS	Neuroblastoma rat sarcoma viral oncogenes
NSCLC	Non-small-cell lung cancer
ORR	Objective response rate
OS	Overall survival
P+D	Placebo + docetaxel
PD-1	Programmed death 1
PDEδ	Prenyl-binding protein
PD-L1	Programmed death ligand 1
PFS	Progression-free survival
PI	Proteasome inhibitor
PI3K	Phosphatidylinositol 3-kinase
PLCε	Phospholipase Cε
RAF	Rapidly accelerated fibrosarcoma
RAL	Ras-like protein
RalGDS	RAS-related protein Ral
RAS	Rat sarcoma
RHOA	Ras homolog gene family, member A
ROS1	Ros proto-oncogene 1
RTK	Receptor tyrosine kinase
S+D	Selumetinib + docetaxel
SHP2	Protein tyrosine phosphatase 2
S-IIP	Switch-II pocket
SOS-1	Son of sevenless homologue 1
STAT	Signal transducer and activator of transcription
TCR	T-cell receptor
TEAEs	Treatment emergent adverse events
TP53	Tumor suppressor protein 53
TRAEs	Treatment related adverse events
VEGF	Vascular endothelial growth factor
WT	Wild-type