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. 2023 Jul 27;24(15):12017. doi: 10.3390/ijms241512017

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Dynamic gene expression changes in the iALI model upon SARS-CoV-2 infection. Expression levels of (A) inflammatory cytokines/chemokines, including (a) genes that were upregulated early and the expression of which gradually increased upon SARS-CoV-2 infection, from 1 to 4 dpi; (b) genes that were upregulated early, the expression of which remained constant between 1 and 4 dpi; (c) genes that were upregulated specifically at 1 dpi and were then downregulated at 4 dpi; and (d) genes that became upregulated at 4 dpi. Expression of genes implicated in the (B) interferon response, (C) extracellular matrix and (D) epithelial/stromal gene upon infection. Normalized expression levels (counts per million reads) were quantified via RNA-seq using data from [14] (human iPSC-derived AT2 cells infected or not with SARS-CoV-2).