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Effect of AZT on Vpr-induced apoptosis
| Pseudotyped virus | % of apoptotic cellsa |
|---|---|
| Mock | 4 |
| Vpr−/VSV-G+ | 5 |
| Vpr+-T/VSV-G+ | 14 |
| Vpr+-T/VSV-G+ + AZTb | 15 |
| Vpr+/VSV-G+ | 25 |
| Vpr+/VSV-G+ + AZT | 13 |
The percentage of apoptotic cells in each infected culture was determined by costaining of infected cells with annexin V- FITC and PI at 48 h p.i. and analysis by flow cytometry.
+ AZT, AZT (5 μM) was added to Jurkat cell cultures 2 h prior to infection and maintained during the course of infection.
