Figure 1.
Alt a 1 binds quercetin stronger in conjunction with iron. Protein surface of the major Alternaria allergen Alt a 1 and a close-up of amino acids (red) in 4 Å vicinity of iron(quercetin)2 (FeQ2) complexes as a (a) monomer, (b) dimer, (c) tetramer, (d) hexamer [13] with FeQ2 (sticks with carbons in yellow, oxygens in red, and iron shown as a grey sphere). (e) Summary of calculated affinities as derived from in silico docking of quercetin in conjunction with iron to mono-, di-, tetra-, and hexameric Alt a 1.