Summary of the interaction between monoaminergic and peptidergic neurotransmission centrally via areas of interest in migraine biology and the symptom correlates for each area (dural vasculature, trigeminal ganglion, and SPG are not included). VIP is likely involved in peripheral mechanisms of dural vasodilatation and the parasympathetic reflex via the dural vasculature, SSN and SPG. DA; dopamine, NA; noradrenaline, and 5HT; serotonin. Free to use sagittal brain image https://upload.wikimedia.org/wikipedia/commons/a/a0/Brain_human_sagittal_section.svgby, Patrick J. Lynch, medical illustrator, CC BY 2.5 <https://creativecommons.org/licenses/by/2.5>, via Wikimedia Commons. The authors have annotated the figure for the purpose of this article.