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. 2023 Aug 5;24(15):12462. doi: 10.3390/ijms241512462

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Total variations in GSH and antioxidant enzymatic systems, monooxygenases and phase II enzymes in rat liver following IQOS exposure. (a) Total amount of GSH. (b) GSSG red, GSH Px, DT−diaphorase, SOD (left y axis), catalase and XO (right y axis). (c) COX. (d) Phase I enzymes: PROD (CYP2B1/2), EROD (CYP1A1), MROD (CYP2A1), ECOD (not specific, CYP1A1, 1A2 and 2B) (left y axis); pNPH (CYP2E1) and APND (right y axis). (e) GST and UDPGT. Data are expressed as mean ± S.D. p < 0.05 *, p < 0.01 **, p < 0.001 ***.