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. 2023 Aug 4;24(15):12421. doi: 10.3390/ijms241512421

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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fPS-MP deposition in the brain. Green, fluorescent particles were detected in most regions of the brain. Representative images taken with the iRiS Digital Cell Imaging System are shown. Brain coronal sections from HFD-induced obese mice treated orally with fPS-MPs (0.125 µg/mouse per day) for 6 weeks show fPS-MPs (green) bound to cells (nuclei, blue, Hoechst). Scale bar: 100 µm. Regions marked: (A) whole brain (HY, hypothalamus; LV, lateral ventricle); (B) cortex; (C) striatum (ST); (D) substantia nigra (SN); (E) hippocampus (HIP); (F) dentate gyrus (DG); (G) hippocampal CA1; and (H) hippocampal CA3.