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Cell exposure to asbestos and iron homeostasis. Functional groups (e.g., -Si-O− groups) on the surface of the fibrous silica will complex host sources of intracellular iron. There is a loss of metal required for critical functions in the cell. Mitochondria are especially vulnerable as processes in this organelle demonstrate significant dependence on the availability of this metal (e.g., Krebs cycle and electron transport system).
