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. 2023 Jul 26;24(15):11942. doi: 10.3390/ijms241511942

Figure 6.

Figure 6

Overexpression of mir-10 enhances mutant Huntingtin (mHtt) induced phenotypes. (A) Overexpression of mir-10 decreases the longevity of Htt.Q120 expressing (HD) flies. (B) mir-10 overexpression leads to a significant decrease in the eclosion rate of both HD flies and Htt.Q25 expressing controls. The graph shows the relative eclosion of HD and control flies in the presence or absence of a mir-10 transgene as percent of non-expressing siblings. (C) Overexpression of mir-10 decreases the number of visible rhabdomeres per ommatidia in the eyes of HD flies. The boxes show 25%, 50%, and 75% values, whiskers represent 10% and 90% values. (D) Overexpression of mir-10 does not have a statistically significant effect on the climbing speed of either HD or control flies. Bars show average values, error bars indicate the standard error of mean (SEM). Significance levels (* p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001) are shown only between corresponding mir-10 overexpressing and non-overexpressing categories.