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. 2023 Jul 26;24(15):11942. doi: 10.3390/ijms241511942

Figure 10.

Figure 10

Overexpression of mir-1010 ameliorates HD phenotypes. (A) Overexpression of mir-1010 has a positive effect on the longevity of both Htt.Q25 expressing (control), and Htt.Q120 expressing (HD) flies. (B) mir-1010 overexpression leads to increased eclosion rate of HD flies. The graph shows the relative eclosion of flies expressing Htt.Q120 or Htt.Q25 in the presence or absence of a mir-1010 transgene as percent of non-expressing siblings. (C) Overexpression of mir-1010 leads to an increase in the number of rhabdomeres per ommatidia in the eyes of HD flies. The boxes show 25%, 50%, and 75% values, whiskers represent 10% and 90% values. (D) Overexpression of mir-1010 increases the climbing speed of HD flies. Bars show average values, error bars indicate SEM. Significance levels (** p ≤ 0.01, *** p ≤ 0.001) are shown only between corresponding mir-1010 overexpressing and non-overexpressing categories.