Table 1.
miRNAs significantly misregulated in flies expressing mutant Huntingtin.
| miRNA | Base Mean (CPM) 1 | log2(FC) 2 | Adjusted p Value 3 | Human Orthologs 4 |
|---|---|---|---|---|
| dme-miR-4986-3p | 6.02 | −1.33 | 2.29 × 10−2 | |
| dme-miR-2279-5p | 5.21 | −1 | 4.03 × 10−2 | |
| dme-miR-219-5p | 23.94 | −0.76 | 7.21 × 10−5 | hsa-miR-219-5p $# |
| dme-miR-1010-5p | 25.86 | −0.7 | 6.29 × 10−7 | hsa-miR-412 # |
| dme-miR-92a-5p | 39.12 | −0.54 | 8.01 × 10−5 | hsa-miR-25 $#, hsa-hsa-miR-92a $#, hsa-miR92b $#, hsa-miR-32 #, hsa-miR-363 #, hsa-miR-367 #, hsa-miR-885-5p # |
| dme-miR-307a-3p | 213.68 | −0.42 | 1.37 × 10−2 | |
| dme-miR-304-5p | 27.69 | −0.38 | 3.85 × 10−2 | hsa-miR-216a $# |
| dme-miR-929-5p | 117.03 | −0.36 | 2.60 × 10−3 | |
| dme-miR-274-5p | 1271.69 | −0.35 | 1.35 × 10−2 | hsa-miR-758 # |
| dme-miR-87-3p | 199.18 | −0.35 | 2.54 × 10−14 | |
| dme-miR-1006-3p | 198.74 | −0.29 | 4.75 × 10−7 | |
| dme-miR-137-3p | 934.73 | −0.28 | 3.60 × 10−3 | hsa-miR-137 $# |
| dme-miR-998-3p | 158.26 | −0.22 | 2.12 × 10−2 | hsa-miR-21* #, hsa-miR-29a #, hsa-miR-29b #, hsa-miR-29c #, hsa-miR-593* # |
| dme-miR-2b-3p | 2802.63 | −0.21 | 2.79 × 10−3 | hsa-miR-499-3p # |
| dme-miR-1000-5p | 936.13 | −0.21 | 5.86 × 10−4 | |
| dme-miR-13b-3p | 2027.42 | −0.16 | 1.57 × 10−2 | hsa-miR-499-3p # |
| dme-miR-11-5p | 256.11 | 0.18 | 3.29 × 10−3 | hsa-miR-27b $#, hsa-miR-27a #, hsa-miR-128 #, hsa-miR-499-3p #, hsa-miR-768-3p # |
| dme-miR-999-3p | 79,593.87 | 0.19 | 2.28 × 10−2 | |
| dme-miR-927-5p | 5481.4 | 0.28 | 4.59 × 10−3 | |
| dme-miR-932-3p | 89.88 | 0.29 | 3.17 × 10−3 | |
| dme-miR-993-3p | 306.58 | 0.3 | 2.56 × 10−2 | hsa-miR-100* $, hsa-mir-99a* #, hsa-miR-99b* #, hsa-miR-556-5p # |
| dme-miR-284-5p | 1428.7 | 0.31 | 7.61 × 10−5 | |
| dme-miR-285-5p | 309.28 | 0.34 | 2.44 × 10−5 | hsa-miR-29a $#, hsa-miR-29b $#, hsa-miR-29c $#, hsa-miR-21* #, hsa-miR-593* # |
| dme-miR-7-5p | 52,010.66 | 0.35 | 4.16 × 10−2 | hsa-miR-7 $#, hsa-miR-9* #, hsa-miR-548-3p #, hsa-miR-146a #, hsa-miR-146b-5p # |
| dme-miR-2c-5p | 214.24 | 0.42 | 1.62 × 10−4 | hsa-miR-499-3p # |
| dme-miR-10-5p | 1393.19 | 0.52 | 2.47 × 10−2 | hsa-miR-10a $#, hsa-miR-10b $#, hsa-miR-99a $, hsa-miR-100 $, hsa-miR-146b-3p # |
| dme-miR-278-5p | 618.26 | 0.52 | 7.61 × 10−5 | |
| dme-miR-6-3p | 70.38 | 0.65 | 8.73 × 10−3 | hsa-miR-27a #, hsa-miR-27b #, hsa-miR-128 #, hsa-miR-499-3p #, hsa-miR-768-3p # |
| dme-miR-305-3p | 487.46 | 0.71 | 4.85 × 10−5 | |
| dme-miR-286-3p | 16.1 | 0.79 | 2.54 × 10−14 | hsa-miR-134 # |
| dme-miR-4969-5p | 31.1 | 0.88 | 5.42 × 10−13 | |
| dme-miR-961-5p | 1.63 | 4.02 | 1.77 × 10−4 | hsa-miR-133a # |
1: Mean number of sequence read counts per million reads (CPM). 2: log2 fold change (FC) of miRNA expression levels in mutant Huntingtin-expressing flies with respect to control flies. 3: p value of likelihood ratio test adjusted for multiple comparison testing using the Benjamini–Hochberg method. 4: Human orthologs are based on [18]. $: ≥70% identity with human miRNAs, #: homology at the 5′ end with human miRNAs.