Table 1.
Summary of studies investigating ADAMTS proteoglycanases in TAAD patients.
| Enzyme | Disease | Expression | Level | Localization | Reference |
|---|---|---|---|---|---|
| ADAMTS1 | TAAD (type B) | Decreased | mRNA | Tissue | [64] |
| MFS | Decreased | protein | Tissue | [50] | |
| TAAD | Increased | protein | Plasma/Tissue | [65] | |
| TAAD | Increased | protein | Tissue | [66] | |
| TAAD | Unchanged | mRNA | Tissue | [6] | |
| TAAD | Increased | mRNA | Tissue | [67] | |
| TAAD | Increased | mRNA/protein | Tissue | [68] | |
| TAAD (type A) | Increased | mRNA/protein | Serum/Tissue | [69] | |
| ADAMTS4 | TAAD | Increased | mRNA/protein | Tissue | [68] |
| TAAD | Unchanged | mRNA | Tissue | [6] | |
| TAAD | Increased | protein | Tissue | [53] | |
| TAAD (type A) | Increased | mRNA/protein | Serum/Tissue | [69] | |
| ADAMTS5 | TAAD | Increased | protein | Tissue | [66] |
| TAAD | Decreased | mRNA | Tissue | [6] | |
| TAAD | Decreased | mRNA | Tissue | [70] | |
| TAAD | Decreased | protein | Plasma | [71] | |
| ADAMTS9 | TAAD | Unchanged | mRNA | Tissue | [6] |
| ADAMTS20 | TAAD | Unchanged | mRNA | Tissue | [6] |